# Glycine and D-Cycloserine in Schizophrenia

> **NCT00000372** · PHASE3 · WITHDRAWN · sponsor: **Massachusetts General Hospital**

## Conditions studied

- Schizophrenia

## Interventions

- **DRUG:** D-cycloserine
- **DRUG:** Glycine
- **DRUG:** Clozapine
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT00000372
- **Lead sponsor:** Massachusetts General Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** WITHDRAWN
- **Start date:** 1998-03
- **Primary completion:** 2005-11
- **Final completion:** 2005-11
- **Target enrollment:** 0 (ACTUAL)
- **Why stopped:** Pairing D-Cycloserine with Clozapine was found to worsen negative side effects in patients with Schizophrenia, so the study was suspended.
- **Last updated:** 2014-06-12


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00000372

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00000372, "Glycine and D-Cycloserine in Schizophrenia". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT00000372. Licensed CC0.

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