# A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis

> **NCT00000639** · NA · COMPLETED · sponsor: **National Institute of Allergy and Infectious Diseases (NIAID)** · enrollment: 400 (—)

## Conditions studied

- Meningitis, Cryptococcal
- HIV Infections

## Interventions

- **DRUG:** Itraconazole
- **DRUG:** Flucytosine
- **DRUG:** Fluconazole
- **DRUG:** Amphotericin B

## Key facts

- **NCT ID:** NCT00000639
- **Lead sponsor:** National Institute of Allergy and Infectious Diseases (NIAID)
- **Sponsor class:** NIH
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** —
- **Primary completion:** —
- **Final completion:** 1997-09
- **Target enrollment:** 400 (—)
- **Last updated:** 2021-11-02

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00000639

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00000639, "A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis". Retrieved via MORVS 2026-09-29 from https://api.morvs.ai/clinical/NCT00000639. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*