# Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS

> **NCT00001013** · PHASE3 · COMPLETED · sponsor: **National Institute of Allergy and Infectious Diseases (NIAID)** · enrollment: 364 (—)

## Conditions studied

- Pneumonia, Pneumocystis Carinii
- HIV Infections

## Interventions

- **DRUG:** Trimetrexate glucuronate
- **DRUG:** Pentamidine isethionate
- **DRUG:** Sulfamethoxazole-Trimethoprim
- **DRUG:** Leucovorin calcium

## Key facts

- **NCT ID:** NCT00001013
- **Lead sponsor:** National Institute of Allergy and Infectious Diseases (NIAID)
- **Sponsor class:** NIH
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** —
- **Primary completion:** —
- **Final completion:** 1991-09
- **Target enrollment:** 364 (—)
- **Last updated:** 2021-11-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00001013

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00001013, "Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT00001013. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*