# A Treatment Study for Premenstrual Syndrome (PMS)

> **NCT00001259** · PHASE1 · COMPLETED · sponsor: **National Institute of Mental Health (NIMH)** · enrollment: 60 (actual)

## Conditions studied

- Premenstrual Syndrome
- Menstruation Disturbances

## Interventions

- **DRUG:** Leuprolide
- **DRUG:** Estradiol Patches
- **DRUG:** Progesterone
- **DRUG:** Placebo patch
- **DRUG:** Placebo injection
- **DRUG:** Placebo suppository

## Key facts

- **NCT ID:** NCT00001259
- **Lead sponsor:** National Institute of Mental Health (NIMH)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 1992-08-11
- **Primary completion:** 2020-02-06
- **Final completion:** 2020-02-06
- **Target enrollment:** 60 (ACTUAL)
- **Last updated:** 2023-03-02


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00001259

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00001259, "A Treatment Study for Premenstrual Syndrome (PMS)". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT00001259. Licensed CC0.

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