# Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Ewing's Sarcoma or Primitive Neuroectodermal Tumor

> **NCT00002643** · PHASE2 · COMPLETED · sponsor: **National Cancer Institute (NCI)** · enrollment: 130 (actual)

## Conditions studied

- Neutropenia
- Sarcoma

## Interventions

- **BIOLOGICAL:** filgrastim
- **DRUG:** amifostine trihydrate
- **DRUG:** cyclophosphamide
- **DRUG:** doxorubicin hydrochloride
- **DRUG:** etoposide
- **DRUG:** ifosfamide
- **DRUG:** topotecan hydrochloride
- **DRUG:** vincristine sulfate
- **PROCEDURE:** conventional surgery
- **RADIATION:** low-LET cobalt-60 gamma ray therapy
- **RADIATION:** low-LET electron therapy
- **RADIATION:** low-LET photon therapy

## Key facts

- **NCT ID:** NCT00002643
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 1995-04
- **Primary completion:** 2003-06
- **Final completion:** —
- **Target enrollment:** 130 (ACTUAL)
- **Last updated:** 2013-02-01

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00002643

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00002643, "Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Ewing's Sarcoma or Primitive Neuroectodermal Tumor". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT00002643. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*