# Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia

> **NCT00002704** · PHASE2 · COMPLETED · sponsor: **National Cancer Institute (NCI)** · enrollment: 156 (actual)

## Conditions studied

- Leukemia

## Interventions

- **BIOLOGICAL:** filgrastim
- **DRUG:** asparaginase
- **DRUG:** cyclophosphamide
- **DRUG:** daunorubicin hydrochloride
- **DRUG:** dexamethasone
- **DRUG:** etoposide
- **DRUG:** leucovorin calcium
- **DRUG:** liposomal cytarabine
- **DRUG:** mercaptopurine
- **DRUG:** mesna
- **DRUG:** methotrexate
- **DRUG:** therapeutic hydrocortisone
- **DRUG:** thiotepa
- **DRUG:** vincristine sulfate
- **RADIATION:** low-LET electron therapy
- **RADIATION:** low-LET photon therapy

## Key facts

- **NCT ID:** NCT00002704
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 1996-01
- **Primary completion:** 2004-06
- **Final completion:** —
- **Target enrollment:** 156 (ACTUAL)
- **Last updated:** 2013-02-01


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00002704

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00002704, "Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia". Retrieved via AI Analytics 2026-07-05 from https://api.ai-analytics.org/clinical/NCT00002704. Licensed CC0.

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