# High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Standard Combination Chemotherapy in Treating Women With High-Risk Breast Cancer

> **NCT00002784** · PHASE3 · COMPLETED · sponsor: **ETOP IBCSG Partners Foundation** · enrollment: 344 (actual)

## Conditions studied

- Breast Cancer

## Interventions

- **BIOLOGICAL:** filgrastim
- **DRUG:** CMF regimen
- **DRUG:** cyclophosphamide
- **DRUG:** doxorubicin hydrochloride
- **DRUG:** epirubicin hydrochloride
- **DRUG:** fluorouracil
- **DRUG:** mesna
- **DRUG:** methotrexate
- **DRUG:** tamoxifen citrate
- **PROCEDURE:** peripheral blood stem cell transplantation
- **RADIATION:** low-LET electron therapy
- **RADIATION:** low-LET photon therapy

## Key facts

- **NCT ID:** NCT00002784
- **Lead sponsor:** ETOP IBCSG Partners Foundation
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 1996-06
- **Primary completion:** 2011-08
- **Final completion:** 2011-12
- **Target enrollment:** 344 (ACTUAL)
- **Last updated:** 2013-04-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00002784

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00002784, "High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Standard Combination Chemotherapy in Treating Women With High-Risk Breast Cancer". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT00002784. Licensed CC0.

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