Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome

NCT00002798 · clinicaltrials.gov ↗

PHASE3

Phase

COMPLETED

Status

880

Enrollment

NIH

Sponsor class

Conditions

Childhood Acute Erythroleukemia (M6)
Childhood Acute Megakaryocytic Leukemia (M7)
Childhood Acute Monoblastic Leukemia (M5a)
Childhood Acute Monocytic Leukemia (M5b)
Childhood Acute Myeloblastic Leukemia With Maturation (M2)
Childhood Acute Myeloblastic Leukemia Without Maturation (M1)
Childhood Acute Myelomonocytic Leukemia (M4)
Childhood Myelodysplastic Syndromes
Chronic Myelomonocytic Leukemia
de Novo Myelodysplastic Syndromes
Refractory Anemia
Refractory Anemia With Excess Blasts
Refractory Anemia With Excess Blasts in Transformation
Refractory Anemia With Ringed Sideroblasts
Secondary Myelodysplastic Syndromes
Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies

Interventions

DRUG: asparaginase
DRUG: daunorubicin hydrochloride
DRUG: fludarabine phosphate
DRUG: therapeutic hydrocortisone
PROCEDURE: allogeneic bone marrow transplantation
RADIATION: 3-dimensional conformal radiation therapy
BIOLOGICAL: filgrastim
DRUG: cytarabine
DRUG: idarubicin
DRUG: dexamethasone
DRUG: thioguanine
DRUG: etoposide
DRUG: methotrexate
DRUG: cyclophosphamide
BIOLOGICAL: aldesleukin
DRUG: busulfan

Sponsor

National Cancer Institute (NCI)