# Combination Chemotherapy in Treating Children With Progressive Brain Tumors

> **NCT00002944** · PHASE3 · COMPLETED · sponsor: **Children's Oncology Group** · enrollment: 428 (actual)

## Conditions studied

- Brain Tumors
- Central Nervous System Tumors

## Interventions

- **DRUG:** carboplatin
- **DRUG:** lomustine
- **DRUG:** procarbazine hydrochloride
- **DRUG:** thioguanine
- **DRUG:** vincristine sulfate

## Key facts

- **NCT ID:** NCT00002944
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 1997-04
- **Primary completion:** 2006-02
- **Final completion:** 2012-04
- **Target enrollment:** 428 (ACTUAL)
- **Last updated:** 2013-09-09

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00002944

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00002944, "Combination Chemotherapy in Treating Children With Progressive Brain Tumors". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT00002944. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*