# Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Patients With Stage III or Stage IV Low-Grade Non-Hodgkin's Lymphoma

> **NCT00003204** · PHASE3 · COMPLETED · sponsor: **National Cancer Institute (NCI)** · enrollment: 515 (actual)

## Conditions studied

- Stage III Grade 1 Follicular Lymphoma
- Stage III Grade 2 Follicular Lymphoma
- Stage III Grade 3 Follicular Lymphoma
- Stage III Small Lymphocytic Lymphoma
- Stage IV Grade 1 Follicular Lymphoma
- Stage IV Grade 2 Follicular Lymphoma
- Stage IV Grade 3 Follicular Lymphoma
- Stage IV Small Lymphocytic Lymphoma

## Interventions

- **DRUG:** cyclophosphamide
- **DRUG:** fludarabine phosphate
- **DRUG:** vincristine sulfate
- **DRUG:** prednisone
- **BIOLOGICAL:** rituximab
- **OTHER:** laboratory biomarker analysis

## Key facts

- **NCT ID:** NCT00003204
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 1998-03
- **Primary completion:** 2006-05
- **Final completion:** —
- **Target enrollment:** 515 (ACTUAL)
- **Last updated:** 2013-02-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00003204

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00003204, "Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Patients With Stage III or Stage IV Low-Grade Non-Hodgkin's Lymphoma". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT00003204. Licensed CC0.

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