# Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade Glioma

> **NCT00003375** · PHASE2,PHASE3 · COMPLETED · sponsor: **Radiation Therapy Oncology Group** · enrollment: 370 (actual)

## Conditions studied

- Brain and Central Nervous System Tumors

## Interventions

- **DRUG:** lomustine
- **DRUG:** procarbazine hydrochloride
- **DRUG:** vincristine sulfate
- **RADIATION:** radiation therapy

## Key facts

- **NCT ID:** NCT00003375
- **Lead sponsor:** Radiation Therapy Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 1998-10
- **Primary completion:** 2005-08
- **Final completion:** 2018-05-14
- **Target enrollment:** 370 (ACTUAL)
- **Last updated:** 2024-07-09

## Collaborators

- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00003375

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00003375, "Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade Glioma". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT00003375. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*