# Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation or Isotretinoin in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Acute Lymphocytic Leukemia

> **NCT00003619** · PHASE1,PHASE2 · COMPLETED · sponsor: **Drexel University College of Medicine**

## Conditions studied

- Chronic Myeloproliferative Disorders
- Leukemia
- Myelodysplastic Syndromes
- Thrombocytopenia

## Interventions

- **BIOLOGICAL:** filgrastim
- **DIETARY_SUPPLEMENT:** vitamin E
- **DRUG:** busulfan
- **DRUG:** cytarabine
- **DRUG:** etoposide
- **DRUG:** fludarabine phosphate
- **DRUG:** isotretinoin
- **DRUG:** topotecan hydrochloride
- **PROCEDURE:** bone marrow ablation with stem cell support
- **PROCEDURE:** peripheral blood stem cell transplantation

## Key facts

- **NCT ID:** NCT00003619
- **Lead sponsor:** Drexel University College of Medicine
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 1998-02
- **Primary completion:** —
- **Final completion:** 2004-04
- **Target enrollment:** — (—)
- **Last updated:** 2013-06-26


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00003619

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00003619, "Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation or Isotretinoin in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Acute Lymphocytic Leukemia". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT00003619. Licensed CC0.

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