# Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma

> **NCT00003937** · PHASE3 · COMPLETED · sponsor: **Children's Oncology Group** · enrollment: 253 (actual)

## Conditions studied

- Cardiac Toxicity
- Sarcoma

## Interventions

- **DRUG:** cisplatin
- **DRUG:** dexrazoxane hydrochloride
- **DRUG:** doxorubicin hydrochloride
- **DRUG:** etoposide
- **DRUG:** ifosfamide
- **DRUG:** methotrexate
- **PROCEDURE:** conventional surgery

## Key facts

- **NCT ID:** NCT00003937
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 1999-09
- **Primary completion:** 2004-03
- **Final completion:** 2008-06
- **Target enrollment:** 253 (ACTUAL)
- **Last updated:** 2014-08-05

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00003937

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00003937, "Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT00003937. Licensed CC0.

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