# Combination Chemotherapy in Treating Patients With Previously Untreated Rhabdomyosarcoma

> **NCT00003958** · PHASE3 · COMPLETED · sponsor: **Children's Oncology Group** · enrollment: 702 (actual)

## Conditions studied

- Adult Malignant Mesenchymoma
- Adult Rhabdomyosarcoma
- Alveolar Childhood Rhabdomyosarcoma
- Childhood Malignant Mesenchymoma
- Embryonal Childhood Rhabdomyosarcoma
- Embryonal-botryoid Childhood Rhabdomyosarcoma
- Nonmetastatic Childhood Soft Tissue Sarcoma
- Previously Untreated Childhood Rhabdomyosarcoma
- Stage I Adult Soft Tissue Sarcoma
- Stage II Adult Soft Tissue Sarcoma
- Stage III Adult Soft Tissue Sarcoma

## Interventions

- **BIOLOGICAL:** dactinomycin
- **DRUG:** vincristine sulfate
- **DRUG:** cyclophosphamide
- **PROCEDURE:** therapeutic conventional surgery
- **RADIATION:** radiation therapy
- **DRUG:** topotecan hydrochloride
- **BIOLOGICAL:** filgrastim
- **BIOLOGICAL:** sargramostim
- **OTHER:** laboratory biomarker analysis

## Key facts

- **NCT ID:** NCT00003958
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2002-09
- **Primary completion:** 2007-10
- **Final completion:** —
- **Target enrollment:** 702 (ACTUAL)
- **Last updated:** 2013-06-17

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00003958

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00003958, "Combination Chemotherapy in Treating Patients With Previously Untreated Rhabdomyosarcoma". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT00003958. Licensed CC0.

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