# Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans Syndrome

> **NCT00004311** · PHASE2 · COMPLETED · sponsor: **National Center for Research Resources (NCRR)**

## Conditions studied

- Acanthosis Nigricans
- Polycystic Ovary Syndrome

## Interventions

- **DRUG:** leuprolide acetate
- **DRUG:** spironolactone

## Key facts

- **NCT ID:** NCT00004311
- **Lead sponsor:** National Center for Research Resources (NCRR)
- **Sponsor class:** NIH
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 1989-07
- **Primary completion:** —
- **Final completion:** 1996-01
- **Target enrollment:** — (—)
- **Last updated:** 2005-06-24

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00004311

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00004311, "Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans Syndrome". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT00004311. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*