# Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer

> **NCT00005036** · PHASE3 · COMPLETED · sponsor: **National Cancer Institute (NCI)** · enrollment: 560 (actual)

## Conditions studied

- Mucinous Adenocarcinoma of the Colon
- Mucinous Adenocarcinoma of the Rectum
- Recurrent Colon Cancer
- Recurrent Rectal Cancer
- Signet Ring Adenocarcinoma of the Colon
- Signet Ring Adenocarcinoma of the Rectum
- Stage IIIA Colon Cancer
- Stage IIIA Rectal Cancer
- Stage IIIB Colon Cancer
- Stage IIIB Rectal Cancer
- Stage IIIC Colon Cancer
- Stage IIIC Rectal Cancer
- Stage IVA Colon Cancer
- Stage IVA Rectal Cancer
- Stage IVB Colon Cancer
- Stage IVB Rectal Cancer

## Interventions

- **DRUG:** irinotecan hydrochloride
- **DRUG:** oxaliplatin
- **DRUG:** leucovorin calcium
- **DRUG:** fluorouracil
- **PROCEDURE:** quality-of-life assessment

## Key facts

- **NCT ID:** NCT00005036
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 1999-11
- **Primary completion:** 2006-12
- **Final completion:** —
- **Target enrollment:** 560 (ACTUAL)
- **Last updated:** 2013-05-03

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00005036

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00005036, "Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer". Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/clinical/NCT00005036. Licensed CC0.

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