# Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE)

> **NCT00005777** · PHASE3 · TERMINATED · sponsor: **NICHD Neonatal Research Network** · enrollment: 220 (actual)

## Conditions studied

- Bronchopulmonary Dysplasia
- Respiratory Distress Syndrome
- Infant, Newborn
- Infant, Low Birth Weight
- Infant, Small for Gestational Age
- Infant, Premature

## Interventions

- **PROCEDURE:** Minimal mechanical ventilation management
- **PROCEDURE:** Routine mechanical ventilation management
- **DRUG:** Dexamethasone
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT00005777
- **Lead sponsor:** NICHD Neonatal Research Network
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 1998-02
- **Primary completion:** 1998-09
- **Final completion:** 2002-09
- **Target enrollment:** 220 (ACTUAL)
- **Why stopped:** The trial was halted because of unanticipated nonrespiratory adverse events related to dexamethasone therapy.
- **Last updated:** 2015-06-08

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00005777

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00005777, "Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE)". Retrieved via AI Analytics 2026-07-20 from https://api.ai-analytics.org/clinical/NCT00005777. Licensed CC0.

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