# Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined Immunodeficiency Undergoing Donor Bone Marrow Transplant

> **NCT00008450** · PHASE1 · COMPLETED · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 6 (actual)

## Conditions studied

- Adenosine Deaminase Deficiency
- Autosomal Recessive Disorder
- Immune System Disorder
- Purine-Nucleoside Phosphorylase Deficiency
- Severe Combined Immunodeficiency
- Severe Combined Immunodeficiency With Absence of T and B Cells
- X-Linked Severe Combined Immunodeficiency

## Interventions

- **PROCEDURE:** Allogeneic Bone Marrow Transplantation
- **DRUG:** Cyclosporine
- **OTHER:** Laboratory Biomarker Analysis
- **DRUG:** Mycophenolate Mofetil
- **PROCEDURE:** Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation
- **RADIATION:** Total-Body Irradiation

## Key facts

- **NCT ID:** NCT00008450
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 1997-08-11
- **Primary completion:** 2011-10-25
- **Final completion:** 2018-12-26
- **Target enrollment:** 6 (ACTUAL)
- **Last updated:** 2019-07-29

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00008450

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00008450, "Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined Immunodeficiency Undergoing Donor Bone Marrow Transplant". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT00008450. Licensed CC0.

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