# Combination Chemotherapy, Surgery, and Radiation Therapy With or Without Dexrazoxane and Trastuzumab in Treating Women With Stage III or Stage IV Breast Cancer

> **NCT00016276** · PHASE3 · TERMINATED · sponsor: **National Cancer Institute (NCI)** · enrollment: 396 (actual)

## Conditions studied

- Cardiac Toxicity
- Inflammatory Breast Cancer
- Stage IIIA Breast Cancer
- Stage IIIB Breast Cancer
- Stage IV Breast Cancer

## Interventions

- **DRUG:** dexrazoxane hydrochloride
- **DRUG:** doxorubicin hydrochloride
- **DRUG:** cyclophosphamide
- **DRUG:** paclitaxel
- **BIOLOGICAL:** trastuzumab
- **PROCEDURE:** therapeutic conventional surgery
- **RADIATION:** radiation therapy
- **DRUG:** tamoxifen citrate
- **OTHER:** laboratory biomarker analysis

## Key facts

- **NCT ID:** NCT00016276
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2001-05
- **Primary completion:** 2005-03
- **Final completion:** —
- **Target enrollment:** 396 (ACTUAL)
- **Why stopped:** Administratively complete.
- **Last updated:** 2013-01-16


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00016276

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00016276, "Combination Chemotherapy, Surgery, and Radiation Therapy With or Without Dexrazoxane and Trastuzumab in Treating Women With Stage III or Stage IV Breast Cancer". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT00016276. Licensed CC0.

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