# Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure

> **NCT00016523** · PHASE3 · TERMINATED · sponsor: **NICHD Neonatal Research Network** · enrollment: 420 (actual)

## Conditions studied

- Infant, Newborn
- Infant, Low Birth Weight
- Infant, Small for Gestational Age
- Infant, Premature
- Respiratory Distress Syndrome (RDS)
- Sepsis
- Pneumonia
- Hypertension, Pulmonary

## Interventions

- **DRUG:** Inhaled nitric oxide
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT00016523
- **Lead sponsor:** NICHD Neonatal Research Network
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2001-01
- **Primary completion:** 2003-09
- **Final completion:** 2006-05
- **Target enrollment:** 420 (ACTUAL)
- **Why stopped:** Preliminary results showed increased intraventricular hemorrhage (IVH) in experimental arm
- **Last updated:** 2017-09-26

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00016523

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00016523, "Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure". Retrieved via AI Analytics 2026-08-11 from https://api.ai-analytics.org/clinical/NCT00016523. Licensed CC0.

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