# Sequenced Treatment Alternatives to Relieve Depression (STAR*D)

> **NCT00021528** · PHASE4 · COMPLETED · sponsor: **National Institute of Mental Health (NIMH)** · enrollment: 4000 (—)

## Conditions studied

- Depression

## Interventions

- **DRUG:** citalopram
- **DRUG:** BuproprionSR
- **DRUG:** buspirone
- **DRUG:** Lithium
- **DRUG:** mirtazapine
- **DRUG:** nortriptyline
- **DRUG:** sertraline
- **DRUG:** tranylcypromine
- **DRUG:** VenlafaxineXR
- **BEHAVIORAL:** Cognitive Therapy
- **DRUG:** T3 (Triiodothyronine)

## Key facts

- **NCT ID:** NCT00021528
- **Lead sponsor:** National Institute of Mental Health (NIMH)
- **Sponsor class:** NIH
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2001-07
- **Primary completion:** —
- **Final completion:** 2006-09
- **Target enrollment:** 4000 (—)
- **Last updated:** 2009-09-25


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00021528

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00021528, "Sequenced Treatment Alternatives to Relieve Depression (STAR*D)". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT00021528. Licensed CC0.

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