# Combination Chemotherapy With or Without Bevacizumab Compared With Bevacizumab Alone in Treating Patients With Advanced or Metastatic Colorectal Cancer That Has Been Previously Treated

> **NCT00025337** · PHASE3 · COMPLETED · sponsor: **National Cancer Institute (NCI)** · enrollment: 880 (actual)

## Conditions studied

- Adenocarcinoma of the Colon
- Adenocarcinoma of the Rectum
- Recurrent Colon Cancer
- Recurrent Rectal Cancer
- Stage III Colon Cancer
- Stage III Rectal Cancer
- Stage IV Colon Cancer
- Stage IV Rectal Cancer

## Interventions

- **BIOLOGICAL:** bevacizumab
- **DRUG:** oxaliplatin
- **DRUG:** leucovorin calcium
- **DRUG:** fluorouracil

## Key facts

- **NCT ID:** NCT00025337
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2001-09
- **Primary completion:** 2007-04
- **Final completion:** —
- **Target enrollment:** 880 (ACTUAL)
- **Last updated:** 2013-01-24


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00025337

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00025337, "Combination Chemotherapy With or Without Bevacizumab Compared With Bevacizumab Alone in Treating Patients With Advanced or Metastatic Colorectal Cancer That Has Been Previously Treated". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT00025337. Licensed CC0.

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