# Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event.

> **NCT00037115** · PHASE4 · WITHDRAWN · sponsor: **MidAmerica Neuroscience Research Foundation at Rowe Neurology Institute**

## Conditions studied

- Demyelinating Disorders
- Multiple Sclerosis
- Optic Neuritis
- Myelitis
- Neuritis

## Interventions

- **DRUG:** interferon beta 1a
- **DRUG:** methotrexate
- **DRUG:** methylprednisolone

## Key facts

- **NCT ID:** NCT00037115
- **Lead sponsor:** MidAmerica Neuroscience Research Foundation at Rowe Neurology Institute
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** WITHDRAWN
- **Start date:** 2002-05
- **Primary completion:** 2002-12
- **Final completion:** 2002-12
- **Target enrollment:** 0 (ACTUAL)
- **Why stopped:** Lack of funding
- **Last updated:** 2018-04-12

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00037115

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00037115, "Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event.". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT00037115. Licensed CC0.

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