# Rituximab, Rasburicase, and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Advanced B-Cell Leukemia or Lymphoma

> **NCT00057811** · PHASE2 · COMPLETED · sponsor: **Children's Oncology Group** · enrollment: 97 (actual)

## Conditions studied

- Childhood Burkitt Lymphoma
- Childhood Diffuse Large Cell Lymphoma
- Childhood Immunoblastic Large Cell Lymphoma
- Stage I Childhood Large Cell Lymphoma
- Stage I Childhood Small Noncleaved Cell Lymphoma
- Stage II Childhood Large Cell Lymphoma
- Stage II Childhood Small Noncleaved Cell Lymphoma
- Stage III Childhood Large Cell Lymphoma
- Stage III Childhood Small Noncleaved Cell Lymphoma
- Stage IV Childhood Large Cell Lymphoma
- Stage IV Childhood Small Noncleaved Cell Lymphoma
- Untreated Childhood Acute Lymphoblastic Leukemia

## Interventions

- **DRUG:** doxorubicin hydrochloride
- **DRUG:** cyclophosphamide
- **DRUG:** methotrexate
- **DRUG:** rasburicase
- **DRUG:** leucovorin calcium
- **DRUG:** prednisone
- **DRUG:** methylprednisolone
- **BIOLOGICAL:** filgrastim
- **BIOLOGICAL:** rituximab
- **DRUG:** cytarabine
- **DRUG:** etoposide
- **DRUG:** vincristine sulfate
- **DRUG:** hydrocortisone sodium succinate
- **OTHER:** laboratory biomarker analysis

## Key facts

- **NCT ID:** NCT00057811
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2004-06
- **Primary completion:** 2009-10
- **Final completion:** 2014-07
- **Target enrollment:** 97 (ACTUAL)
- **Last updated:** 2014-09-19

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00057811

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00057811, "Rituximab, Rasburicase, and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Advanced B-Cell Leukemia or Lymphoma". Retrieved via AI Analytics 2026-07-26 from https://api.ai-analytics.org/clinical/NCT00057811. Licensed CC0.

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