Donor Stem Cell Transplant With No or Low-Intensity Chemotherapy Using Sirolimus and Treated Immune Cells to Treat Blood and Lymph Cancers

Stopped Premature closure due to inability to accrue to ARM IVD, cohorts 1 and 2

Conditions

• Lymphoma
• Leukemia
• Myeloproliferative Disorders
• Multiple Myleoma
• Myelodysplastic Syndrome

Interventions

• DRUG: Rituximab
• DRUG: Fludarabine
• DRUG: Etoposide
• DRUG: Doxorubicin
• DRUG: Vincristine
• DRUG: Cyclophosphamide
• PROCEDURE: Peripheral blood stem cell (PBSC) transplantation
• GENETIC: T cell donor lymphocyte infusion (DLI) with unmanipulated donor T cells
• DRUG: Prednisone
• PROCEDURE: Allogeneic hematopoietic stem cell transplant (HSCT)
• DRUG: Filgrastim
• GENETIC: T-Rapa cell Donor Lymphocyte Infusion (DLI)

Sponsor

National Cancer Institute (NCI)