Lymphocyte Depletion and Stem Cell Transplantation to Treat Severe Systemic Lupus Erythematosus

NCT00076752 · clinicaltrials.gov ↗

PHASE2

Phase

COMPLETED

Status

9

Enrollment

NIH

Sponsor class

Conditions

Lupus Erythematosus, Systemic

Interventions

DRUG: fludarabine phosphate
DRUG: cyclophosphamide
BIOLOGICAL: Rituxan (rituximab)
BIOLOGICAL: filgrastim
DRUG: methylprednisolone
OTHER: immunologic technique
OTHER: laboratory biomarker analysis
PROCEDURE: autologous hematopoietic stem cell transplantation
DRUG: Diphenhydramine
DRUG: Mesna

Sponsor

National Cancer Institute (NCI)