# High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade Gliomas

> **NCT00078988** · PHASE3 · COMPLETED · sponsor: **Children's Oncology Group** · enrollment: 1 (actual)

## Conditions studied

- Brain Tumor
- Central Nervous System Tumor

## Interventions

- **BIOLOGICAL:** filgrastim
- **DRUG:** carboplatin
- **DRUG:** etoposide
- **DRUG:** isotretinoin
- **DRUG:** thiotepa
- **PROCEDURE:** autologous bone marrow transplantation
- **PROCEDURE:** peripheral blood stem cell transplantation

## Key facts

- **NCT ID:** NCT00078988
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2004-10
- **Primary completion:** 2006-09
- **Final completion:** 2006-09
- **Target enrollment:** 1 (ACTUAL)
- **Last updated:** 2015-05-07

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00078988

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00078988, "High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade Gliomas". Retrieved via AI Analytics 2026-09-25 from https://api.ai-analytics.org/clinical/NCT00078988. Licensed CC0.

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