Cyclophosphamide and Fludarabine Followed by Vaccine Therapy, Gene-Modified White Blood Cell Infusions, and Aldesleukin in Treating Patients With Metastatic Melanoma

NCT00091104 · clinicaltrials.gov ↗

PHASE1

Phase

COMPLETED

Status

136

Enrollment

NIH

Sponsor class

Conditions

Melanoma (Skin)

Interventions

BIOLOGICAL: MART-1:27-35 peptide vaccine
BIOLOGICAL: aldesleukin
BIOLOGICAL: filgrastim
BIOLOGICAL: incomplete Freund's adjuvant
BIOLOGICAL: therapeutic autologous lymphocytes
BIOLOGICAL: therapeutic tumor infiltrating lymphocytes
DRUG: cyclophosphamide
DRUG: fludarabine phosphate
PROCEDURE: autologous hematopoietic stem cell transplantation
PROCEDURE: in vitro-treated peripheral blood stem cell transplantation
RADIATION: total-body irradiation

Sponsor

National Institutes of Health Clinical Center (CC)

Collaborators

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