# Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity

> **NCT00092222** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 75 (actual)

## Conditions studied

- Lymphoproliferative Disorder
- HHV-8
- Malignancy
- HIV

## Interventions

- **DRUG:** Etoposide
- **DRUG:** Interferon-alpha
- **DRUG:** Rituximab
- **DRUG:** Zidovudine
- **DRUG:** Liposomal Doxorubicin
- **DRUG:** Bortezomib
- **DRUG:** Valganciclovir
- **DRUG:** Doxorubicin
- **DRUG:** Vincristine
- **DRUG:** Cyclophosphamide
- **DRUG:** Filgrastim (G-CSF)
- **DRUG:** Prednisone
- **DRUG:** Sirolimus
- **OTHER:** Observation Only

## Key facts

- **NCT ID:** NCT00092222
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2004-10-28
- **Primary completion:** 2026-10-01
- **Final completion:** 2026-10-01
- **Target enrollment:** 75 (ACTUAL)
- **Last updated:** 2026-04-29


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00092222

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00092222, "Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT00092222. Licensed CC0.

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