# Safety and Effectiveness of S-adenosyl-l-methionine (SAMe) for the Treatment of Major Depression

> **NCT00101452** · NA · COMPLETED · sponsor: **Maurizio Fava, MD** · enrollment: 199 (actual)

## Conditions studied

- Depression

## Interventions

- **DRUG:** S-adenosyl-l-methionine
- **DRUG:** Escitalopram
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT00101452
- **Lead sponsor:** Maurizio Fava, MD
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2005-04
- **Primary completion:** 2010-06
- **Final completion:** 2010-06
- **Target enrollment:** 199 (ACTUAL)
- **Last updated:** 2017-04-04

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00101452

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00101452, "Safety and Effectiveness of S-adenosyl-l-methionine (SAMe) for the Treatment of Major Depression". Retrieved via AI Analytics 2026-07-01 from https://api.ai-analytics.org/clinical/NCT00101452. Licensed CC0.

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