# Estrogen Replacement to Reduce Risk of Neurologic Injury After Coronary Artery Bypass Graft Surgery

> **NCT00123539** · NA · TERMINATED · sponsor: **National Heart, Lung, and Blood Institute (NHLBI)** · enrollment: 334 (—)

## Conditions studied

- Coronary Disease
- Cardiovascular Diseases
- Heart Diseases
- Neurologic Manifestations

## Interventions

- **DRUG:** Estrogen Replacement Therapy
- **PROCEDURE:** Surgery

## Key facts

- **NCT ID:** NCT00123539
- **Lead sponsor:** National Heart, Lung, and Blood Institute (NHLBI)
- **Sponsor class:** NIH
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2001-06
- **Primary completion:** —
- **Final completion:** 2005-08
- **Target enrollment:** 334 (—)
- **Why stopped:** DSMB stopped the study based on conclusion of likely futility of treatment on the primary outcome.
- **Last updated:** 2016-07-29


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00123539

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00123539, "Estrogen Replacement to Reduce Risk of Neurologic Injury After Coronary Artery Bypass Graft Surgery". Retrieved via AI Analytics 2026-09-26 from https://api.ai-analytics.org/clinical/NCT00123539. Licensed CC0.

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