# Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly

> **NCT00212147** · NA · COMPLETED · sponsor: **National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)** · enrollment: 444 (estimated)

## Conditions studied

- Avitaminosis
- Delirium, Dementia, Amnestic, Cognitive Disorders

## Interventions

- **DRUG:** General anesthesia with nitrous oxide
- **DRUG:** General anesthesia without nitrous oxide

## Key facts

- **NCT ID:** NCT00212147
- **Lead sponsor:** National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- **Sponsor class:** NIH
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2003-09
- **Primary completion:** 2008-08
- **Final completion:** 2008-08
- **Target enrollment:** 444 (ESTIMATED)
- **Last updated:** 2022-08-08


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00212147

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00212147, "Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT00212147. Licensed CC0.

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