# Treatment of Orthostatic Hypotension in Autonomic Failure

> **NCT00223691** · PHASE1 · COMPLETED · sponsor: **Vanderbilt University** · enrollment: 389 (actual)

## Conditions studied

- Autonomic Failure
- Orthostatic Hypotension

## Interventions

- **DRUG:** Atomoxetine
- **DRUG:** Acarbose
- **DRUG:** Pyridostigmine Bromide
- **DRUG:** Yohimbine
- **DRUG:** Midodrine HCl
- **DRUG:** placebo
- **DRUG:** Modafinil
- **DRUG:** Octreotide
- **OTHER:** water intake
- **DRUG:** Diphenhydramine Hydrochloride
- **DRUG:** Ranitidine HCL
- **DRUG:** Tranylcypromine
- **DRUG:** Ergotamine/ Caffeine
- **DRUG:** Celecoxib
- **DRUG:** Pseudoephedrine
- **DRUG:** Methylphenidate
- **DRUG:** Indomethacin
- **DRUG:** Ibuprofen
- **DRUG:** Oxymetazoline 0.05% nasal solution
- **DIETARY_SUPPLEMENT:** Bovril

## Key facts

- **NCT ID:** NCT00223691
- **Lead sponsor:** Vanderbilt University
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2002-03
- **Primary completion:** 2017-01
- **Final completion:** 2017-01
- **Target enrollment:** 389 (ACTUAL)
- **Last updated:** 2017-01-18


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00223691

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00223691, "Treatment of Orthostatic Hypotension in Autonomic Failure". Retrieved via AI Analytics 2026-09-04 from https://api.ai-analytics.org/clinical/NCT00223691. Licensed CC0.

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