# Treatment of Supine Hypertension in Autonomic Failure

> **NCT00223717** · PHASE1 · COMPLETED · sponsor: **Vanderbilt University** · enrollment: 152 (actual)

## Conditions studied

- Hypertension

## Interventions

- **DRUG:** Clonidine
- **DRUG:** Nitroglycerin transdermal
- **DRUG:** Dipyridamole/ Aspirin (Aggrenox)
- **DRUG:** Desmopressin (DDAVP)
- **DRUG:** Sildenafil
- **DRUG:** Nifedipine
- **DRUG:** Hydralazine
- **DRUG:** Hydrochlorothiazide
- **DRUG:** Placebo
- **DRUG:** Bosentan
- **DRUG:** Diltiazem
- **DRUG:** Eplerenone
- **DRUG:** guanfacine
- **DIETARY_SUPPLEMENT:** L-arginine
- **DRUG:** captopril
- **DRUG:** carbidopa
- **DRUG:** losartan
- **DRUG:** metoprolol tartrate
- **DRUG:** nebivolol hydrochloride
- **DRUG:** prazosin hydrochloride

## Key facts

- **NCT ID:** NCT00223717
- **Lead sponsor:** Vanderbilt University
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2001-01
- **Primary completion:** 2017-01
- **Final completion:** 2017-01
- **Target enrollment:** 152 (ACTUAL)
- **Last updated:** 2017-10-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00223717

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00223717, "Treatment of Supine Hypertension in Autonomic Failure". Retrieved via AI Analytics 2026-07-29 from https://api.ai-analytics.org/clinical/NCT00223717. Licensed CC0.

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