# Estrogen for Treating Depression in Menopausal Women With Hot Flashes and Insomnia

> **NCT00227942** · PHASE4 · COMPLETED · sponsor: **Hadine Joffe, MD** · enrollment: 86 (actual)

## Conditions studied

- Sleep Initiation and Maintenance Disorders
- Depression

## Interventions

- **DRUG:** Estrogen Replacement Therapy
- **DRUG:** Zolpidem
- **DRUG:** placebo

## Key facts

- **NCT ID:** NCT00227942
- **Lead sponsor:** Hadine Joffe, MD
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2003-08
- **Primary completion:** —
- **Final completion:** 2007-11
- **Target enrollment:** 86 (ACTUAL)
- **Last updated:** 2014-05-26

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00227942

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00227942, "Estrogen for Treating Depression in Menopausal Women With Hot Flashes and Insomnia". Retrieved via AI Analytics 2026-07-26 from https://api.ai-analytics.org/clinical/NCT00227942. Licensed CC0.

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