Recombinant Human Superoxide Dismutase (rhSOD) and Vascular Reactivity

Conditions

• Inflammation

Interventions

• DRUG: LPS 2 ng/kg intravenous (IV) bolus
• DRUG: rhSOD 82,000 IU (8.2 mg)/min intraarterially
• DRUG: Norepinephrine 60, 120, 240 pmol/min intraarterially over 5 min/dose level (two times; pre-dose and +3.5 hrs)
• DRUG: Acetylcholine 6.25, 12.5, 25 nmol/min intraarterially over 3 min/dose level (two times; pre-dose and +3.5 hrs)
• DRUG: Glyceroltrinitrate (nitroglycerine) 4, 8, 16 nmol/min over 3 min/dose level (two times; pre-dose and +3.5 hrs)

Sponsor

Medical University of Vienna

Collaborators

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