# The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection

> **NCT00273377** · PHASE3 · COMPLETED · sponsor: **The Cleveland Clinic** · enrollment: 2000 (estimated)

## Conditions studied

- Surgical Wound Infection
- Surgery, Colon

## Interventions

- **OTHER:** Mild intraoperative hypercapnia (50 mmHg vs. 30 mmHg)
- **OTHER:** Supplemental oxygen (80% vs. 30%)
- **DRUG:** Dexamethasone
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT00273377
- **Lead sponsor:** The Cleveland Clinic
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2002-05
- **Primary completion:** 2007-12
- **Final completion:** 2007-12
- **Target enrollment:** 2000 (ESTIMATED)
- **Last updated:** 2016-06-29


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00273377

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00273377, "The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection". Retrieved via AI Analytics 2026-07-20 from https://api.ai-analytics.org/clinical/NCT00273377. Licensed CC0.

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