# A Study to Evaluate Rituximab in Combination With Methotrexate in Methotrexate-Naive Patients With Active Rheumatoid Arthritis

> **NCT00299104** · PHASE3 · COMPLETED · sponsor: **Genentech, Inc.** · enrollment: 755 (actual)

## Conditions studied

- Rheumatoid Arthritis

## Interventions

- **DRUG:** folate
- **DRUG:** methotrexate
- **DRUG:** methylprednisolone
- **DRUG:** placebo
- **DRUG:** rituximab

## Key facts

- **NCT ID:** NCT00299104
- **Lead sponsor:** Genentech, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2006-01
- **Primary completion:** 2008-09
- **Final completion:** 2013-07
- **Target enrollment:** 755 (ACTUAL)
- **Last updated:** 2017-07-28

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00299104

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00299104, "A Study to Evaluate Rituximab in Combination With Methotrexate in Methotrexate-Naive Patients With Active Rheumatoid Arthritis". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT00299104. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*