# Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH)

> **NCT00303459** · PHASE4 · COMPLETED · sponsor: **Actelion** · enrollment: 334 (actual)

## Conditions studied

- Pulmonary Arterial Hypertension

## Interventions

- **DRUG:** bosentan
- **DRUG:** placebo

## Key facts

- **NCT ID:** NCT00303459
- **Lead sponsor:** Actelion
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2006-05
- **Primary completion:** 2013-12
- **Final completion:** 2013-12
- **Target enrollment:** 334 (ACTUAL)
- **Last updated:** 2025-02-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00303459

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00303459, "Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH)". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT00303459. Licensed CC0.

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