# Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)

> **NCT00310180** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 10273 (actual)

## Conditions studied

- Breast Adenocarcinoma
- Hormone Receptor Positive
- Stage IA Breast Cancer AJCC v7
- Stage IB Breast Cancer AJCC v7
- Stage IIA Breast Cancer AJCC v6 and v7
- Stage IIB Breast Cancer AJCC v6 and v7
- Stage IIIB Breast Cancer AJCC v7

## Interventions

- **DRUG:** Anastrozole
- **DRUG:** Exemestane
- **OTHER:** Laboratory Biomarker Analysis
- **DRUG:** Letrozole
- **OTHER:** Quality-of-Life Assessment
- **RADIATION:** Radiation Therapy
- **DRUG:** Tamoxifen Citrate

## Key facts

- **NCT ID:** NCT00310180
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2006-04-07
- **Primary completion:** 2018-03-02
- **Final completion:** 2030-09-30
- **Target enrollment:** 10273 (ACTUAL)
- **Last updated:** 2026-04-24

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00310180

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00310180, "Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)". Retrieved via AI Analytics 2026-08-11 from https://api.ai-analytics.org/clinical/NCT00310180. Licensed CC0.

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