# A Study of 6(S)-5-MTHF Among Serotonin Reuptake Inhibitor(SSRI)-Resistant Outpatients With Major Depressive Disorder (MDD)

> **NCT00321152** · PHASE4 · COMPLETED · sponsor: **Massachusetts General Hospital** · enrollment: 150 (estimated)

## Conditions studied

- Major Depressive Disorder

## Interventions

- **OTHER:** 6(S)-5-MTHF (a Medical Food)

## Key facts

- **NCT ID:** NCT00321152
- **Lead sponsor:** Massachusetts General Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2006-11
- **Primary completion:** 2008-08
- **Final completion:** 2010-06
- **Target enrollment:** 150 (ESTIMATED)
- **Last updated:** 2010-06-08

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00321152

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00321152, "A Study of 6(S)-5-MTHF Among Serotonin Reuptake Inhibitor(SSRI)-Resistant Outpatients With Major Depressive Disorder (MDD)". Retrieved via AI Analytics 2026-07-26 from https://api.ai-analytics.org/clinical/NCT00321152. Licensed CC0.

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