# Phase I Study of Intravenous Triapine (IND # 68338) in Combination With Pelvic Radiation Therapy With or Without Weekly Intravenous Cisplatin Chemotherapy for Locally Advanced Cervical, Vaginal, or Pelvic Gynecologic Malignancies

> **NCT00335998** · PHASE1 · COMPLETED · sponsor: **National Cancer Institute (NCI)** · enrollment: 24 (actual)

## Conditions studied

- Recurrent Cervical Cancer
- Recurrent Ovarian Epithelial Cancer
- Recurrent Vaginal Cancer
- Recurrent Vulvar Cancer
- Stage III Vaginal Cancer
- Stage IIIA Cervical Cancer
- Stage IIIA Ovarian Epithelial Cancer
- Stage IIIA Vulvar Cancer
- Stage IIIB Cervical Cancer
- Stage IIIB Ovarian Epithelial Cancer
- Stage IIIB Vulvar Cancer
- Stage IIIC Ovarian Epithelial Cancer
- Stage IIIC Vulvar Cancer
- Stage IV Ovarian Epithelial Cancer
- Stage IVA Cervical Cancer
- Stage IVA Vaginal Cancer
- Stage IVB Cervical Cancer
- Stage IVB Vaginal Cancer

## Interventions

- **DRUG:** triapine
- **OTHER:** laboratory biomarker analysis
- **RADIATION:** external beam radiation therapy
- **RADIATION:** brachytherapy
- **DRUG:** cisplatin
- **OTHER:** pharmacological study

## Key facts

- **NCT ID:** NCT00335998
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2006-03
- **Primary completion:** 2008-10
- **Final completion:** —
- **Target enrollment:** 24 (ACTUAL)
- **Last updated:** 2013-01-11


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00335998

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00335998, "Phase I Study of Intravenous Triapine (IND # 68338) in Combination With Pelvic Radiation Therapy With or Without Weekly Intravenous Cisplatin Chemotherapy for Locally Advanced Cervical, Vaginal, or Pelvic Gynecologic Malignancies". Retrieved via AI Analytics 2026-07-26 from https://api.ai-analytics.org/clinical/NCT00335998. Licensed CC0.

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