# Effects of Thiazide Diuretics on Sympathetic Nervous System in Hypertension

> **NCT00353652** · PHASE4 · COMPLETED · sponsor: **University of Texas Southwestern Medical Center** · enrollment: 166 (actual)

## Conditions studied

- Hypertension

## Interventions

- **DRUG:** Study#1: chlorthalidone (CTD), titrated dose
- **DRUG:** Study #1: spironolactone (SP), titrated dose
- **DRUG:** Study# 2 chlorthalidone (CTD), fixed dose
- **DRUG:** Study# 2 spironolactone (SP), fixed dose
- **DRUG:** Study# 2 irbsesartan (IR), fixed dose

## Key facts

- **NCT ID:** NCT00353652
- **Lead sponsor:** University of Texas Southwestern Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2005-01
- **Primary completion:** 2013-01
- **Final completion:** 2013-01
- **Target enrollment:** 166 (ACTUAL)
- **Last updated:** 2019-02-06

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00353652

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00353652, "Effects of Thiazide Diuretics on Sympathetic Nervous System in Hypertension". Retrieved via AI Analytics 2026-08-01 from https://api.ai-analytics.org/clinical/NCT00353652. Licensed CC0.

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