# Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma

> **NCT00354835** · PHASE3 · COMPLETED · sponsor: **Children's Oncology Group** · enrollment: 481 (actual)

## Conditions studied

- Adult Rhabdomyosarcoma
- Childhood Alveolar Rhabdomyosarcoma
- Childhood Botryoid-Type Embryonal Rhabdomyosarcoma
- Childhood Embryonal Rhabdomyosarcoma
- Localized Childhood Soft Tissue Sarcoma
- Rhabdomyosarcoma
- Sarcoma
- Stage I Adult Soft Tissue Sarcoma AJCC v7
- Stage II Adult Soft Tissue Sarcoma AJCC v7
- Stage III Adult Soft Tissue Sarcoma AJCC v7

## Interventions

- **DRUG:** Cyclophosphamide
- **BIOLOGICAL:** Dactinomycin
- **DRUG:** Irinotecan Hydrochloride
- **OTHER:** Laboratory Biomarker Analysis
- **OTHER:** Questionnaire Administration
- **RADIATION:** Radiation Therapy
- **DRUG:** Vincristine Sulfate

## Key facts

- **NCT ID:** NCT00354835
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2006-12-26
- **Primary completion:** 2014-12-31
- **Final completion:** 2022-12-31
- **Target enrollment:** 481 (ACTUAL)
- **Last updated:** 2023-01-31

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00354835

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00354835, "Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma". Retrieved via AI Analytics 2026-06-30 from https://api.ai-analytics.org/clinical/NCT00354835. Licensed CC0.

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