# Effectiveness of Pacemaker With Closed Loop Stimulation Compared to Pacemakers With and Without Standard Rate Response

> **NCT00355797** · PHASE4 · COMPLETED · sponsor: **Biotronik, Inc.** · enrollment: 1491 (actual)

## Conditions studied

- Bradycardia

## Interventions

- **DEVICE:** Closed Loop Stimulation (CLS)
- **DEVICE:** Standard Rate Adaptive (R) Technology
- **DEVICE:** Non-rate adaptive (DDD) pacing

## Key facts

- **NCT ID:** NCT00355797
- **Lead sponsor:** Biotronik, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2006-05
- **Primary completion:** 2008-02
- **Final completion:** 2010-12
- **Target enrollment:** 1491 (ACTUAL)
- **Last updated:** 2012-12-20


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00355797

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00355797, "Effectiveness of Pacemaker With Closed Loop Stimulation Compared to Pacemakers With and Without Standard Rate Response". Retrieved via AI Analytics 2026-07-26 from https://api.ai-analytics.org/clinical/NCT00355797. Licensed CC0.

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