Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Transplant and Cyclophosphamide, Mycophenolate Mofetil, Tacrolimus, and Sirolimus in Treating Patients With Primary Immunodeficiency Disorders or Noncancerous Inherited Disorders

Stopped Low accrual

Conditions

• Immunodeficiency Syndrome
• Severe Aplastic Anemia
• Genetic Disorder

Interventions

• PROCEDURE: Allogeneic Bone Marrow Transplantation
• DRUG: Cyclophosphamide
• DRUG: Fludarabine Phosphate
• OTHER: Laboratory Biomarker Analysis
• DRUG: Mycophenolate Mofetil
• PROCEDURE: Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation
• DRUG: Sirolimus
• DRUG: Tacrolimus
• RADIATION: Total-Body Irradiation

Sponsor

Fred Hutchinson Cancer Center

Collaborators

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