# Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients

> **NCT00369798** · PHASE1 · COMPLETED · sponsor: **National Institute of Mental Health (NIMH)** · enrollment: 100 (actual)

## Conditions studied

- Major Depressive Disorder
- Healthy

## Interventions

- **PROCEDURE:** PET scan
- **DRUG:** Rolipram

## Key facts

- **NCT ID:** NCT00369798
- **Lead sponsor:** National Institute of Mental Health (NIMH)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2006-08-02
- **Primary completion:** 2016-06-16
- **Final completion:** 2016-10-12
- **Target enrollment:** 100 (ACTUAL)
- **Last updated:** 2018-07-05


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00369798

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00369798, "Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients". Retrieved via AI Analytics 2026-07-26 from https://api.ai-analytics.org/clinical/NCT00369798. Licensed CC0.

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