# Umbilical Cord Blood T-Regulatory Cell Infusion Followed by Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Leukemia or Other Hematologic Diseases

> **NCT00376519** · PHASE1 · TERMINATED · sponsor: **Masonic Cancer Center, University of Minnesota** · enrollment: 3 (actual)

## Conditions studied

- Graft Versus Host Disease
- Leukemia
- Lymphoma
- Multiple Myeloma and Plasma Cell Neoplasm
- Myelodysplastic Syndromes
- Secondary Myelofibrosis

## Interventions

- **DRUG:** cyclophosphamide
- **DRUG:** cyclosporine
- **DRUG:** fludarabine phosphate
- **DRUG:** mycophenolate mofetil
- **PROCEDURE:** Treg cell infusion
- **PROCEDURE:** umbilical cord blood transplantation
- **RADIATION:** total-body irradiation

## Key facts

- **NCT ID:** NCT00376519
- **Lead sponsor:** Masonic Cancer Center, University of Minnesota
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2007-05
- **Primary completion:** 2008-03
- **Final completion:** 2008-03
- **Target enrollment:** 3 (ACTUAL)
- **Why stopped:** Slow accrual
- **Last updated:** 2017-12-02


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00376519

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00376519, "Umbilical Cord Blood T-Regulatory Cell Infusion Followed by Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Leukemia or Other Hematologic Diseases". Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/clinical/NCT00376519. Licensed CC0.

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