# Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' Tumor

> **NCT00379340** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **Children's Oncology Group** · enrollment: 395 (actual)

## Conditions studied

- Stage III Kidney Wilms Tumor
- Stage IV Kidney Wilms Tumor

## Interventions

- **RADIATION:** 3-Dimensional Conformal Radiation Therapy
- **PROCEDURE:** Conventional Surgery
- **DRUG:** Cyclophosphamide
- **BIOLOGICAL:** Dactinomycin
- **DRUG:** Doxorubicin Hydrochloride
- **DRUG:** Etoposide
- **DRUG:** Vincristine Sulfate Liposome

## Key facts

- **NCT ID:** NCT00379340
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2007-04-30
- **Primary completion:** 2016-06-30
- **Final completion:** 2026-11-18
- **Target enrollment:** 395 (ACTUAL)
- **Last updated:** 2026-03-17

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00379340

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00379340, "Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' Tumor". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT00379340. Licensed CC0.

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