Decitabine as Maintenance Therapy After Standard Therapy in Treating Patients With Previously Untreated Acute Myeloid Leukemia

NCT00416598 · clinicaltrials.gov ↗

PHASE2

Phase

COMPLETED

Status

546

Enrollment

NIH

Sponsor class

Conditions

Acute Myeloid Leukemia
Acute Myeloid Leukemia With Myelodysplasia-Related Changes
Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11
Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11
Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1
Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A
Untreated Adult Acute Myeloid Leukemia

Interventions

PROCEDURE: Autologous Bone Marrow Transplantation
PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation
DRUG: Busulfan
DRUG: Cytarabine
DRUG: Daunorubicin Hydrochloride
DRUG: Decitabine
DRUG: Etoposide
BIOLOGICAL: Filgrastim
OTHER: Laboratory Biomarker Analysis
OTHER: Pharmacological Study

Sponsor

National Cancer Institute (NCI)